Browse By Cancer Type Result Page of OvirusTdb

The total number of records retrieved from this search are 100. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_59	Adenovirus	Ad5WS1	DNA	Adenoviridae	E1B55K-deleted mutant driven by the E1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (YB-1 gene knockdown)	NA	NA	Crystal violet staining	0.01 MOI	100% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_60	Adenovirus	Ad5WS1	DNA	Adenoviridae	E1B55K-deleted mutant driven by the E1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (YB-1 gene knockdown)	NA	NA	Crystal violet staining	0.1 MOI	90% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_61	Adenovirus	Ad5WS1	DNA	Adenoviridae	E1B55K-deleted mutant driven by the E1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (YB-1 gene knockdown)	NA	NA	Crystal violet staining	1 MOI	40% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_62	Adenovirus	Ad5WS1	DNA	Adenoviridae	E1B55K-deleted mutant driven by the E1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (YB-1 gene knockdown)	NA	NA	Crystal violet staining	10 MOI	2% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_63	Adenovirus	Ad5WS1	DNA	Adenoviridae	E1B55K-deleted mutant driven by the E1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged YB-1 gene overexpressed)	NA	NA	Crystal violet staining	0.001 MOI	100% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_64	Adenovirus	Ad5WS1	DNA	Adenoviridae	E1B55K-deleted mutant driven by the E1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged YB-1 gene overexpressed)	NA	NA	Crystal violet staining	0.01 MOI	90% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_65	Adenovirus	Ad5WS1	DNA	Adenoviridae	E1B55K-deleted mutant driven by the E1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged YB-1 gene overexpressed)	NA	NA	Crystal violet staining	0.1 MOI	60% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_66	Adenovirus	Ad5WS1	DNA	Adenoviridae	E1B55K-deleted mutant driven by the E1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged YB-1 gene overexpressed)	NA	NA	Crystal violet staining	1 MOI	4% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_67	Adenovirus	Ad5WS1	DNA	Adenoviridae	E1B55K-deleted mutant driven by the E1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged YB-1 gene overexpressed)	NA	NA	Crystal violet staining	10 MOI	1% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_68	Adenovirus	Ad5WS1	DNA	Adenoviridae	E1B55K-deleted mutant driven by the E1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)	NA	NA	Crystal violet staining	0.001 MOI	100% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_69	Adenovirus	Ad5WS1	DNA	Adenoviridae	E1B55K-deleted mutant driven by the E1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)	NA	NA	Crystal violet staining	0.01 MOI	100% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_70	Adenovirus	Ad5WS1	DNA	Adenoviridae	E1B55K-deleted mutant driven by the E1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)	NA	NA	Crystal violet staining	0.1 MOI	96% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_71	Adenovirus	Ad5WS1	DNA	Adenoviridae	E1B55K-deleted mutant driven by the E1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)	NA	NA	Crystal violet staining	1 MOI	80% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_72	Adenovirus	Ad5WS1	DNA	Adenoviridae	E1B55K-deleted mutant driven by the E1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)	NA	NA	Crystal violet staining	10 MOI	20% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_73	Adenovirus	AdLacZ	DNA	Adenoviridae	E1/E3-deleted mutant	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged YB-1 gene overexpressed)	NA	NA	Crystal violet staining	0.01 MOI	100% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_74	Adenovirus	AdLacZ	DNA	Adenoviridae	E1/E3-deleted mutant	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged YB-1 gene overexpressed)	NA	NA	Crystal violet staining	0.1 MOI	100% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_75	Adenovirus	AdLacZ	DNA	Adenoviridae	E1/E3-deleted mutant	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged YB-1 gene overexpressed)	NA	NA	Crystal violet staining	1 MOI	100% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_76	Adenovirus	AdLacZ	DNA	Adenoviridae	E1/E3-deleted mutant	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged YB-1 gene overexpressed)	NA	NA	Crystal violet staining	10 MOI	100% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_77	Adenovirus	AdLacZ	DNA	Adenoviridae	E1/E3-deleted mutant	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)	NA	NA	Crystal violet staining	0.01 MOI	100% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_78	Adenovirus	AdLacZ	DNA	Adenoviridae	E1/E3-deleted mutant	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)	NA	NA	Crystal violet staining	0.1 MOI	100% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_79	Adenovirus	AdLacZ	DNA	Adenoviridae	E1/E3-deleted mutant	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)	NA	NA	Crystal violet staining	1 MOI	100% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_80	Adenovirus	AdLacZ	DNA	Adenoviridae	E1/E3-deleted mutant	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)	NA	NA	Crystal violet staining	10 MOI	100% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_81	Adenovirus	Ad5GS3	DNA	Adenoviridae	E1B55K-deleted mutant driven by the MDR1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (YB-1 gene knockdown)	NA	NA	Crystal violet staining	0.01 MOI	100% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_82	Adenovirus	Ad5GS3	DNA	Adenoviridae	E1B55K-deleted mutant driven by the MDR1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (YB-1 gene knockdown)	NA	NA	Crystal violet staining	0.1 MOI	85% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_83	Adenovirus	Ad5GS3	DNA	Adenoviridae	E1B55K-deleted mutant driven by the MDR1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (YB-1 gene knockdown)	NA	NA	Crystal violet staining	1 MOI	35% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_84	Adenovirus	Ad5GS3	DNA	Adenoviridae	E1B55K-deleted mutant driven by the MDR1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (YB-1 gene knockdown)	NA	NA	Crystal violet staining	10 MOI	1% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_85	Adenovirus	Ad5GS3	DNA	Adenoviridae	E1B55K-deleted mutant driven by the MDR1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged YB-1 gene overexpressed)	NA	NA	Crystal violet staining	0.001 MOI	100% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_86	Adenovirus	Ad5GS3	DNA	Adenoviridae	E1B55K-deleted mutant driven by the MDR1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged YB-1 gene overexpressed)	NA	NA	Crystal violet staining	0.01 MOI	90% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_87	Adenovirus	Ad5GS3	DNA	Adenoviridae	E1B55K-deleted mutant driven by the MDR1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged YB-1 gene overexpressed)	NA	NA	Crystal violet staining	0.1 MOI	20% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_88	Adenovirus	Ad5GS3	DNA	Adenoviridae	E1B55K-deleted mutant driven by the MDR1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged YB-1 gene overexpressed)	NA	NA	Crystal violet staining	1 MOI	2% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_89	Adenovirus	Ad5GS3	DNA	Adenoviridae	E1B55K-deleted mutant driven by the MDR1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged YB-1 gene overexpressed)	NA	NA	Crystal violet staining	10 MOI	1% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_90	Adenovirus	Ad5GS3	DNA	Adenoviridae	E1B55K-deleted mutant driven by the MDR1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)	NA	NA	Crystal violet staining	0.001 MOI	100% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_91	Adenovirus	Ad5GS3	DNA	Adenoviridae	E1B55K-deleted mutant driven by the MDR1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)	NA	NA	Crystal violet staining	0.01 MOI	100% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_92	Adenovirus	Ad5GS3	DNA	Adenoviridae	E1B55K-deleted mutant driven by the MDR1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)	NA	NA	Crystal violet staining	0.1 MOI	94% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_93	Adenovirus	Ad5GS3	DNA	Adenoviridae	E1B55K-deleted mutant driven by the MDR1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)	NA	NA	Crystal violet staining	1 MOI	75% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_94	Adenovirus	Ad5GS3	DNA	Adenoviridae	E1B55K-deleted mutant driven by the MDR1 promoter	Yes	No	No	NA	Human breast cancer line	MCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)	NA	NA	Crystal violet staining	10 MOI	16% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26515462
OV_2212	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MDA-MB-435	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	50% cell survival after day 1	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2213	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MDA-MB-435	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	55% cell survival after day 2	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2214	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MDA-MB-435	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	60% cell survival after day 3	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2215	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MDA-MB-435	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	30% cell survival after day 4	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2216	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MDA-MB-435	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	100% cell death after day 5	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2217	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MDA-MB-435	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	40% cell survival after day 1	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2218	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MDA-MB-435	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	20% cell survival after day 2	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2219	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MDA-MB-435	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	10% cell survival after day 3	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2220	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MDA-MB-435	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	100% cell death after day 4	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2221	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MDA-MB-435	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	100% cell death after day 5	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2222	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-7	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	100% cell survival after day 1	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2223	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-7	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	100% cell survival after day 2	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2224	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-7	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	70% cell survival after day 3	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2225	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-7	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	40% cell survival after day 4	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2226	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-7	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	20% cell death after day 5	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2227	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-7	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	90% cell survival after day 1	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2228	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-7	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	60% cell survival after day 2	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2229	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-7	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	30% cell survival after day 3	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2230	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-7	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	10% cell survival after day 4	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2231	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-7	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	100% cell death after day 5	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2232	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	SK-BR-3	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	90% cell survival after day 1	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2233	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	SK-BR-3	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	60% cell survival after day 2	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2234	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	SK-BR-3	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	55% cell survival after day 3	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2235	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	SK-BR-3	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	40% cell survival after day 4	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2236	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	SK-BR-3	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	100% cell death after day 5	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2237	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	SK-BR-3	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	60% cell survival after day 1	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2238	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	SK-BR-3	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	40% cell survival after day 2	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2239	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	SK-BR-3	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	20% cell survival after day 3	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2240	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	SK-BR-3	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	10% cell survival after day 4	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2241	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	SK-BR-3	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	100% cell death after day 5	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2242	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-10A	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	100% cell survival after day 1	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2243	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-10A	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	100% cell survival after day 2	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2244	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-10A	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	100% cell survival after day 3	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2245	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-10A	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	100% cell survival after day 4	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2246	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-10A	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	100% cell survival after day 5	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2247	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-10A	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	100% cell survival after day 1	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2248	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-10A	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	100% cell survival after day 2	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2249	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-10A	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	100% cell survival after day 3	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2250	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-10A	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	90% cell survival after day 4	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2251	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-10A	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	80% cell survival after day 5	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2252	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MDA-MB-435	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for MDA-MB-435(1.0E+6 Ã— 10â¶)	2.0E+7 pfu	NA	Tumor volume decreased by 9 fold after 56 days	Intratumoral	Caspase activation	NA	NA	22108767
OV_2442	Vaccinia virus	GLV-1h151	DNA	Poxviridae	Deteltion of TK gene and addition of GFP gene	Yes	No	No	ATCC	Human breast cancer cell line	MDA-MB-231	3.0E+4 cells per well	NA	LDH release and spectrophometer	0.01 MOI	100% cell survival after day 1	No	No	NA	No response	NA	NA	NA	NA	22258815
OV_2443	Vaccinia virus	GLV-1h151	DNA	Poxviridae	Deteltion of TK gene and addition of GFP gene	Yes	No	No	ATCC	Human breast cancer cell line	MDA-MB-231	3.0E+4 cells per well	NA	LDH release and spectrophometer	0.01 MOI	100% cell survival after day 3	No	No	NA	No response	NA	NA	NA	NA	22258815
OV_2444	Vaccinia virus	GLV-1h151	DNA	Poxviridae	Deteltion of TK gene and addition of GFP gene	Yes	No	No	ATCC	Human breast cancer cell line	MDA-MB-231	3.0E+4 cells per well	NA	LDH release and spectrophometer	0.01 MOI	100% cell survival after day 5	No	No	NA	No response	NA	NA	NA	NA	22258815
OV_2445	Vaccinia virus	GLV-1h151	DNA	Poxviridae	Deteltion of TK gene and addition of GFP gene	Yes	No	No	ATCC	Human breast cancer cell line	MDA-MB-231	3.0E+4 cells per well	NA	LDH release and spectrophometer	0.01 MOI	100% cell survival after day 7	No	No	NA	No response	NA	NA	NA	NA	22258815
OV_2446	Vaccinia virus	GLV-1h151	DNA	Poxviridae	Deteltion of TK gene and addition of GFP gene	Yes	No	No	ATCC	Human breast cancer cell line	MDA-MB-231	3.0E+4 cells per well	NA	LDH release and spectrophometer	0.01 MOI	100% cell survival after day 9	No	No	NA	No response	NA	NA	NA	NA	22258815
OV_2482	Vaccinia virus	GLV-1h151	DNA	Poxviridae	Deteltion of TK gene and addition of GFP gene	Yes	No	No	ATCC	Human breast cancer cell line	MDA-MB-231	3.0E+4 cells per well	NA	LDH release and spectrophometer	0.10 MOI	90% cell survival after day 1	No	No	NA	No response	NA	NA	NA	NA	22258815
OV_2483	Vaccinia virus	GLV-1h151	DNA	Poxviridae	Deteltion of TK gene and addition of GFP gene	Yes	No	No	ATCC	Human breast cancer cell line	MDA-MB-231	3.0E+4 cells per well	NA	LDH release and spectrophometer	0.10 MOI	90% cell survival after day 3	No	No	NA	No response	NA	NA	NA	NA	22258815
OV_2484	Vaccinia virus	GLV-1h151	DNA	Poxviridae	Deteltion of TK gene and addition of GFP gene	Yes	No	No	ATCC	Human breast cancer cell line	MDA-MB-231	3.0E+4 cells per well	NA	LDH release and spectrophometer	0.10 MOI	90% cell survival after day 5	No	No	NA	No response	NA	NA	NA	NA	22258815
OV_2485	Vaccinia virus	GLV-1h151	DNA	Poxviridae	Deteltion of TK gene and addition of GFP gene	Yes	No	No	ATCC	Human breast cancer cell line	MDA-MB-231	3.0E+4 cells per well	NA	LDH release and spectrophometer	0.10 MOI	90% cell survival after day 7	No	No	NA	No response	NA	NA	NA	NA	22258815
OV_2518	Vaccinia virus	GLV-1h151	DNA	Poxviridae	Deteltion of TK gene and addition of GFP gene	Yes	No	No	ATCC	Human breast cancer cell line	MDA-MB-231	3.0E+4 cells per well	NA	LDH release and spectrophometer	1 MOI	70% cell survival after day 1	No	No	NA	No response	NA	NA	NA	NA	22258815
OV_2519	Vaccinia virus	GLV-1h151	DNA	Poxviridae	Deteltion of TK gene and addition of GFP gene	Yes	No	No	ATCC	Human breast cancer cell line	MDA-MB-231	3.0E+4 cells per well	NA	LDH release and spectrophometer	1 MOI	10% cell survival after day 3	No	No	NA	No response	NA	NA	NA	NA	22258815
OV_2520	Vaccinia virus	GLV-1h151	DNA	Poxviridae	Deteltion of TK gene and addition of GFP gene	Yes	No	No	ATCC	Human breast cancer cell line	MDA-MB-231	3.0E+4 cells per well	NA	LDH release and spectrophometer	1 MOI	10% cell survival after day 5	No	No	NA	No response	NA	NA	NA	NA	22258815
OV_2521	Vaccinia virus	GLV-1h151	DNA	Poxviridae	Deteltion of TK gene and addition of GFP gene	Yes	No	No	ATCC	Human breast cancer cell line	MDA-MB-231	3.0E+4 cells per well	NA	LDH release and spectrophometer	1 MOI	10% cell survival after day 7	No	No	NA	No response	NA	NA	NA	NA	22258815
OV_2579	Adenovirus	CNHK600-IL24	DNA	Adenoviridae	Deletion of E1B gene and addition of IL-24 gene	Yes	No	Virus expressing IL-24 gene	Shanghai laboratory animal center, China	Human breast cancer cell line	MDA-MB-231	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	100% cell survival	No	No	NA	No response	NA	Induction of apoptosis in cancer	NA	NA	22640485
OV_2580	Adenovirus	CNHK600-IL24	DNA	Adenoviridae	Deletion of E1B gene and addition of IL-24 gene	Yes	No	Virus expressing IL-24 gene	Shanghai laboratory animal center, China	Human breast cancer cell line	MDA-MB-231	1.0E+5 cells per well	NA	MTT assay	1 MOI	100% cell survival	No	No	NA	No response	NA	Induction of apoptosis in cancer	NA	NA	22640485
OV_2581	Adenovirus	CNHK600-IL24	DNA	Adenoviridae	Deletion of E1B gene and addition of IL-24 gene	Yes	No	Virus expressing IL-24 gene	Shanghai laboratory animal center, China	Human breast cancer cell line	MDA-MB-231	1.0E+5 cells per well	NA	MTT assay	10 MOI	50% cell survival	No	No	NA	No response	NA	Induction of apoptosis in cancer	NA	NA	22640485
OV_2582	Adenovirus	CNHK600-IL24	DNA	Adenoviridae	Deletion of E1B gene and addition of IL-24 gene	Yes	No	Virus expressing IL-24 gene	Shanghai laboratory animal center, China	Human breast cancer cell line	MDA-MB-231	1.0E+5 cells per well	NA	MTT assay	100 MOI	20% cell survival	No	No	NA	No response	NA	Induction of apoptosis in cancer	NA	NA	22640485
OV_2583	Adenovirus	CNHK600-IL24	DNA	Adenoviridae	Deletion of E1B gene and addition of IL-24 gene	Yes	No	Virus expressing IL-24 gene	Shanghai laboratory animal center, China	Human breast cancer cell line	MDA-MB-231	1.0E+5 cells per well	NA	MTT assay	1000 MOI	10% cell survival	No	No	NA	No response	NA	Induction of apoptosis in cancer	NA	NA	22640485
OV_2584	Adenovirus	CNHK600-IL24	DNA	Adenoviridae	Deletion of E1B gene and addition of IL-24 gene	Yes	No	Virus expressing IL-24 gene	Shanghai laboratory animal center, China	Human breast cancer cell line	MDA-MB-231	1.0E+5 cells per well	NA	MTT assay	10000 MOI	All cells are dead	No	No	NA	No response	NA	Induction of apoptosis in cancer	NA	NA	22640485
OV_2585	Adenovirus	CNHK600-IL24	DNA	Adenoviridae	Deletion of E1B gene and addition of IL-24 gene	Yes	No	Virus expressing IL-24 gene	Shanghai laboratory animal center, China	Human breast cancer cell line	MDA-MB-231	NA	NA	NA	NA	NA	Nu/Nu female mice orthotopic for MDA-MB-231 cell line (8.0E+7 cells)	1.0E+8 pfu	NA	Tumor volume comes to 1000mm as compared to normal 2000 after 42 days	Intratumoral	Induction of apoptosis in cancer	NA	NA	22640485
OV_2586	Adenovirus	CNHK600-IL24	DNA	Adenoviridae	Deletion of E1B gene and addition of IL-24 gene	Yes	No	Virus expressing IL-24 gene	Shanghai laboratory animal center, China	Human breast cancer cell line	MDA-MB-231	NA	NA	NA	NA	NA	Nu/Nu female mice orthotopic for MDA-MB-231 cell line (8.0E+7 cells)	2.0E+8 pfu	NA	Tumor volume comes to below 1000mm as compared to normal 2000 after 42 days	Intratumoral	Induction of apoptosis in cancer	NA	NA	22640485
OV_2587	Adenovirus	CNHK600-IL24	DNA	Adenoviridae	Deletion of E1B gene and addition of IL-24 gene	Yes	No	Virus expressing IL-24 gene	Shanghai laboratory animal center, China	Human breast cancer cell line	MDA-MB-231	NA	NA	NA	NA	NA	Nu/Nu female mice orthotopic for MDA-MB-231 cell line (8.0E+7 cells)	4.0E+8 pfu	NA	Tumor volume comes to 500mm as compared to normal 2000 after 42 days	Intratumoral	Induction of apoptosis in cancer	Upregulation of GADD34	NA	22640485
OV_2632	Adenovirus	SG500-dNK	DNA	Adenoviridae	Addition of deoxyribonucleoside kinase	Yes	No	No	Shanghai cell collection	Human breast cancer cell line	MDA-MB-231	1.0E+4 cells per well	NA	MTT assay	1 MOI	80% cell survival after 3 days	No	No	NA	No response	NA	Combination of drug and virus increase the apoptosis process	NA	NA	23000515

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